Figure 1.
Representative chromatograms (left) and pyrograms (right) of GNAS wild-type, GNAS R201C, and GNAS R201H mutations detected in colon cancer. Arrows in chromatograms show mutant, heterozygous peaks. Boxed peaks in pyrograms highlight mutant alleles. Percentages indicate allele frequencies calculated from pyrogram peak intensities.
Table 1.
Tumor molecular and clinical characteristics according to GNAS mutation status.
Table 2.
Clinical and molecular characteristics of GNAS mutant tumors.
Figure 2.
GNAS tumors are associated with a villous morphology.
H&E Photomicrograph of a GNAS mutant, villous adenocarcinoma. The tumor has typical villous morphology with protruding papillae containing a fibrovascular core and lined with adenomatous epithelium.
Table 3.
GNAS mutation frequency in adenomas.
Table 4.
Characteristics of GNAS mutant adenomas.