Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER METABOLISM

GNAS shifts metabolism in pancreatic cancer

Nature Cell Biology volume 20, pages 740–741 (2018)Cite this article

Subjects

Specific combinations of mutations cause unique signalling and metabolic requirements. Concurrent G-protein αs (GNAS) and KRAS mutations in a subset of pancreatic tumours are now shown to inhibit SIK kinases through aberrant cAMP–PKA activation, triggering a metabolic program defined by lipid metabolism and fatty acid oxidation.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Oncogenic GNAS cooperates with KRAS to induce and maintain IPMN pancreatic tumour growth.

References

  1. Witkiewicz, A. K. et al. Nat. Commun. 6, 6744 (2015).

    Article  CAS  Google Scholar 

  2. O’Hayre, M. et al. Nat. Rev. Cancer 13, 412–424 (2013).

    Article  Google Scholar 

  3. Wu, J. et al. Sci. Transl. Med. 3, 92ra66 (2011).

    Article  CAS  Google Scholar 

  4. Patra, K. et al. Nat. Cell Biol. 10.1038/XX (2018).

  5. Amato, E. et al. J. Pathol. 233, 217–227 (2014).

    Article  CAS  Google Scholar 

  6. Pattabiraman, D. R. et al. Science 351, aad3680 (2016).

    Article  Google Scholar 

  7. Rao, R. et al. Cell Cycle 15, 1325–3013 (2016).

    Article  CAS  Google Scholar 

  8. Iglesias-Bartolome, R. et al. Nat. Cell Biol. 17, p.793–803 (2015).

    Article  CAS  Google Scholar 

  9. Henriksson et al. Biochem. J. 444, 503–514 (2012).

    Article  CAS  Google Scholar 

  10. Altarejos, J. Y. & Montminy, M. Nat. Rev. Mol. Cell Biol. 12, 141–151 (2011).

    Article  CAS  Google Scholar 

  11. Shackelford, D. B. & Shaw, R. J. Nat. Rev. Cancer 9, 563–575 (2009).

    Article  CAS  Google Scholar 

  12. Viale, A. et al. Nature 514, 628–632 (2014).

    Article  CAS  Google Scholar 

  13. Cheng, H. et al. Sci. Signal 2, ra35 (2009).

    PubMed  PubMed Central  Google Scholar 

  14. Tarumoto, Y. et al. Mol. Cell 69, 1017–1027 (2018).

    Article  CAS  Google Scholar 

  15. Miranda, F. et al. Cancer Cell 30, 273–289 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Molecular and Cell Biology, The Salk Institute for Biological Studies, San Diego, La Jolla, CA, USA

    Pablo E. Hollstein & Reuben J. Shaw

Authors
  1. Pablo E. Hollstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Reuben J. Shaw
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Reuben J. Shaw.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hollstein, P.E., Shaw, R.J. GNAS shifts metabolism in pancreatic cancer. Nat Cell Biol 20, 740–741 (2018). https://doi.org/10.1038/s41556-018-0120-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-018-0120-5

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer